HSFC was inaugurated by Dr. K Kasturirangan, former Chairman, ISRO on January 30, 2019.

HSFC is responsible for end-to-end mission planning, development of engineering systems for crew survival in space for short and long term missions, involve in crew selection and training, and initiate activities for sustained Human Space Flight missions. HSFC will focus on the development of engineering systems related to the Orbital Module, human centric technology domians of Bioastronautics, Crew training and Life support, basic and applied space sciences, human and robotic space exploration, space habitats and gateways etc. HSFC will also play the role of a technology aggregator to bring together the national expertise in diverse disciplines for multi-directional growth and capacity.